Muscle Twitches caused by Coenzyme Q10 and Carnitine?

[BSGfan]

Update:

I had begun supplementing with Coenzyme Q-10 in the 60-220 mg range for the relief of jaw and facial muscle discomfort induced by a Niacin-Lopid-Mevacor interaction; I had also noted transient muscle cramping in those same areas while on Lopid and Zocor for a number of years, but thought nothing of it.

After a few days of Q-10 supplementation at those high rates I noticed minor finger quivers in one hand. I suspended use and improved.

After plowing through about 30 Q-10 websites I finally found a reference at *www.cancer.org that Q-10 supplementation at high levels can lead to involuntary muscle movements. So it would appear that I now have confirmation that prolonged supplementation in the 180-220 mg range for me did constitute a bit of an overdose.

After more than a month off the Q-10 supplements I am finding that they did appear to have some positive effect; although a bit variable, my facial discomfort is now far less than it was six months ago, and I am experiencing longer periods of relief, days or weeks versus hours or days when I started. That's good.

On the negative side, the carpal tunnel syndrome in my left hand, my more damaged hand, is significantly worse than it was a month or two ago, with constant aches in the palm, a sensation of occasional muscle twitches at the base of the wrist, and an intermittent several times a day feeling of mild electric shocks in the palm and fingers. Now, I do have a bad habit of leaning back on this hand to support my head while reading in bed, or when using my cane, undobutedly leading to a bit of nerve compression, so it is possible my CTS difficulties may be unrelated to my Q-10 use. I intend to ask my doctor to perform additional nerve function tests. If the exams reveal my nerve function has actually improved I might regard my increased symptoms as a sign of healing triggered by the Q-10 use. Conversely, if the condition of my hand has worsened significantly I will be left wondering if the supplements had anything to do with it.

[BSGfan]

Update: in the one month side my last posting here, the minor muscle twitches in my hands have persisted but have subsided considerably in intensity, but I have begun to notice similar mild twitches in my scalp, face, shoulders, feet, and buttocks. I do not know if this has any correlation with the supplements I was taking. It has been about two months since my last dosage of coenzyme Q-10. Assuming these fasciculations are the lingering result of the Q-10, how long can they be expected to last? As previously stated, I had only taken maybe sixty or so dosages of Q-10 in the past four to six months, never higher than 220 mg daily and most in the 100-180 mg range.

My statin induced jaw and facial discomfort is much reduced over what it was six months ago. Perhaps the Q-10 supplementation had some cumulative effect.[/code]